Trigeminal neuralgia in multiple sclerosis patients: a systematic review and meta-analysis of minimally invasive surgical procedures, decompression, and the pain outcomes
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https://doi.org/10.48208/HeadacheMed.2025.38Keywords:
Trigeminal neuralgia, Multiple sclerosis, Stem cells, Gamma knife radiosurgery, Percutaneous balloon compression, Microvascular decompression, Pain outcomesAbstract
Background
Trigeminal neuralgia is characterized by episodes of severe, recurrent, and
debilitating facial pain that can occur in 1 to 2% of the patients who are diagnosed
with multiple sclerosis throughout their lives. Trigeminal neuralgia can be described
as ranges of intense facial pain, like electric shocks, involving the trigeminal nerve.
The aim is to demonstrate the effectiveness of various minimally invasive procedures
for controlling trigeminal neuralgia pain in patients with multiple sclerosis, ranging
from conservative to surgical treatment.
Methods
The review focused on surgical clinical outcomes and treatment modalities related
to trigeminal neuralgia in patients with multiple sclerosis treated with MISS, stem
cells as a modern treatment. The comprehensive search was conducted in several
databases, including ScienceDirect, PubMed/MEDLINE, Google scholar, and the
EMBASE Database, of systematic review using the PRISMA guidelines, R software,
and Excel. PROSPERO ID: 1173874 terms, only studies published in English up to
January 1987 and September 2025.
Results
In our systematic review and meta-analysis, we included a total of N=1559 patients
with trigeminal neuralgia caused by multiple sclerosis. These were broken down into
N=836 patients, or 53%. Among these, N=867 procedures accounted for 55% of
the total. Ch2 192-193.34, df=13, p < .010000.
Conclusion
Trigeminal neuralgia, which can be caused by multiple sclerosis, is a double
combination to the patient's pain. The most common treatments are percutaneous
rhizotomies, including radiofrequency rhizotomy, glycerol rhizotomy, and
percutaneous balloon compression, and anatomical microvascular decompression
and treatment therapy on stem cells.
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Copyright (c) 2025 Daniel Encarnación-Santos, Gennady Chmutin, Nazmin Ahmed, Egor Chmutin, Emmanuel Batista-Geraldino, Bipin Chaurasia (Author)
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