Corpalgia associated with migraine: a case report
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https://doi.org/10.48208/HeadacheMed.2025.30Keywords:
Corpalgia, Body pain, Headache, Migraine, ExtracephalicAbstract
Introduction
Corpalgia is a phenomenon associated with chronic migraine, in which the patient experiences painful hypersensitivity in the cephalic and extracephalic regions.
Objective
To describe the case of a patient with chronic migraine who experienced an episode of corpalgia.
Case report
This is a 19-year-old woman with chronic migraine for over two years. The patient reports that upon waking, in the midst of a migraine episode, she felt intense pressure in the upper and lower limbs corresponding to the side of the headache, lasting approximately 8 hours.
Conclusion
Corpalgia is a rare phenomenon that differs from other symptoms in its characteristics, such as intensity and duration. It can manifest itself uniquely for each patient.
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References
Cuadrado ML, Young WB, Fernández-De-Las-Peñas C, Arias JA, Pareja JA. Migrainous corpalgia: Body pain and allodynia associated with migraine attacks. Cephalalgia 2008;28:87–91. Doi:10.1111/j.1468-2982.2007.01485.x. DOI: https://doi.org/10.1111/j.1468-2982.2007.01485.x
Torregrosa García A, Medrano-Martínez V, Abuomar A, Francés-Pont I, Hernández-Rubio L, Fernández-Izquierdo S, et al. Episodic migraine and chest pain as the first manifestation of small cell lung carcinoma. Clin Case Rep 2020;8:1346–8. Doi:10.1002/ccr3.2618. DOI: https://doi.org/10.1002/ccr3.2618
Kakisaka Y, Ohara T, Katayama S, Suzuki T, Hino-Fukuyo N, Uematsu M, et al. Lower back pain as a symptom of migrainous corpalgia. J Child Neurol 2013;28:676–7. Doi:10.1177/0883073813478170. DOI: https://doi.org/10.1177/0883073813478170
Gayke B, Shinde A, Patharkar P, Khandgaokar M. Formulation and Evaluation of Herbal Capsule in Treatment of Migraine. Int J Res Appl Sci Eng Technol 2023;11:1470–84. Doi:10.22214/ijraset.2023.54876. DOI: https://doi.org/10.22214/ijraset.2023.54876
Florencio LL, Chaves TC, Branisso LB, Gonçalves MC, Dach F, Speciali JG, et al. 2 item Allodynia Symptom Checklist/Brasil: cross-cultural adaptation, internal consistency and reproducibility. Arq Neuropsiquiatr 2012;70:852–6. Doi:10.1590/S0004282X2012001100006. DOI: https://doi.org/10.1590/S0004-282X2012001100006
Bigal ME, Ashina S, Burstein R, Reed ML, Buse D, Serrano D, Lipton RB; AMPP Group. Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology. 2008 Apr 22;70(17):1525-33. Doi:10.1212/01.wnl.0000310645.31020.b1 DOI: https://doi.org/10.1212/01.wnl.0000310645.31020.b1
Suzuki K, Suzuki S, Shiina T, Kobayashi S, Hirata K. Central Sensitization in Migraine: A Narrative Review. J Pain Res 2022;15:2673–82. Doi:10.2147/JPR.S329280. DOI: https://doi.org/10.2147/JPR.S329280
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology 2018;129:343–66. Doi:10.1097/ALN.0000000000002130. DOI: https://doi.org/10.1097/ALN.0000000000002130
Gao J, Wang D, Zhu C, Wang J, Wang T, Xu Y, et al. 1H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice. Journal of Headache and Pain 2024;25. Doi:10.1186/s10194-024-01872-6. DOI: https://doi.org/10.1186/s10194-024-01872-6
Deodato M, Granato A, Martini M, Sabot R, Buoite Stella A, Manganotti P. Instrumental assessment of pressure pain threshold over trigeminal and extra-trigeminal area in people with episodic and chronic migraine: a cross-sectional observational study. Neurological Sciences 2024;45:3923–9. Doi:10.1007/s10072-024-07372-4. DOI: https://doi.org/10.1007/s10072-024-07372-4
Greco R, Demartini C, Francavilla M, Zanaboni AM, Tassorelli C. Antagonism of CGRP Receptor: Central and Peripheral Mechanisms and Mediators in an Animal Model of Chronic Migraine. Cells 2022;11. Doi:10.3390/cells11193092. DOI: https://doi.org/10.3390/cells11193092
Kaya Z, Belder N, Sever-Bahcekapili M, Erdener ŞE, Dönmez-Demir B, Baǧcl C, et al. Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headach. Brain 2025;148:2522–36. Doi:10.1093/brain/awaf015. DOI: https://doi.org/10.1093/brain/awaf015
Iyengar S, Johnson KW, Ossipov MH, Aurora SK. CGRP and the Trigeminal System in Migraine. Headache 2019;59:659–81. Doi:10.1111/head.13529. DOI: https://doi.org/10.1111/head.13529
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Copyright (c) 2025 Marcelo Moraes Valença, Juliana Ramos de Andrade, Rita Santana dos Reis (Author)

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