"I feel an irresistible urge to bang my head against the wall": a case series highlighting agitation and severe pain in cluster headache

Views: 47

Authors

DOI:

https://doi.org/10.48208/HeadacheMed.2025.29

Keywords:

Cluster headache, Psychomotor agitation, Head-banging, Self-injurious behavior, Trigeminal autonomic cephalalgia

Abstract

Abstract
Introduction

Cluster headache is a primary headache disorder characterized by severe, unilateral pain, typically associated with cranial autonomic symptoms, including conjunstival injection, lacrimation, nasal congestion, rhinorrhea, eyelid oedema, forehead and facial sweating, miosis and ptosis.  Beyond these hallmark features, patients often exhibit marked psychomotor agitation, sometimes expressing the wish to engage in head-banging behaviors as an instinctive response to unbearable pain. This case series highlights three such patients.
Cases report
In all cases, appropriate preventive therapies reduced both the frequency of attacks and the desire for self-injurious behavior.
Conclusion
These reports highlight the extreme suffering associated with cluster headache and emphasize the importance of timely recognition and effective management strategies.

Downloads

Download data is not yet available.

References

de Freitas Dias B, Robinson CL, Villar-Martinez MD, Ashina S, Goadsby PJ. Current and Novel Therapies for Cluster Headache: A Narrative Review. Pain Ther. 2025;14(2025):1-19. Doi: 10.1007/s40122-024-00674-7 DOI: https://doi.org/10.1007/s40122-024-00674-7

Xu XH, Li YM, Ren LN, Xu XF, Dai YL, Jin CQ, Yang RR. Cluster headache: understandings of current knowledge and directions for whole process management. Front Neurol. 2024;15(2024):1456517. Doi: 10.3389/fneur.2024.1456517. DOI: https://doi.org/10.3389/fneur.2024.1456517

Burish M. Cluster Headache, SUNCT, and SUNA. Continuum (Minneap Minn). 2024;30(2024):391-410. Doi: 10.1212/CON.0000000000001411. DOI: https://doi.org/10.1212/CON.0000000000001411

Torelli P, Manzoni GC. Behavior during cluster headache. Curr Pain Headache Rep. 2005;9(2005):113-9. Doi: 10.1007/s11916-005-0048-x.

Luerding R, Henkel K, Gaul C, Dresler T, Lindwurm A, Paelecke-Habermann Y, et al. Aggressiveness in different presentations of cluster headache: Results from a controlled multicentric study. Cephalalgia. 2012;32(2012):528-36. Doi: 10.1177/0333102412443336. DOI: https://doi.org/10.1177/0333102412443336

Yulug B, Hanoglu L, Schabitz WR. Headache and spontaneous glabellar ecchymosis: More than a self‐injury behavior? Psychiatry and Clinical Neurosciences. 2014;69(2014):124-. Doi: 10.1111/pcn.12220. DOI: https://doi.org/10.1111/pcn.12220

Torelli P, Manzoni GC. Behavior during cluster headache. Current Pain and Headache Reports. 2005;9(2005):113-9. Doi: 10.1007/s11916-005-0048-x. DOI: https://doi.org/10.1007/s11916-005-0048-x

Bertotti G, Fernandez-Ruiz V, Roldan-Ruiz A, Lopez-Moreno M. Cluster Headache and Migraine Shared and Unique Insights: Neurophysiological Implications, Neuroimaging, and Biomarkers: A Comprehensive Review. J Clin Med. 2025;14(2025). Doi: 10.3390/jcm14072160. DOI: https://doi.org/10.3390/jcm14072160

Abagnale C, Di Renzo A, Giuliani G, Sebastianelli G, Casillo F, Ziccardi L, et al. MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache. J Headache Pain. 2025;26(2025):12. Doi: 10.1186/s10194-024-01920-1. DOI: https://doi.org/10.1186/s10194-024-01920-1

Chiffi D, Di Renzo A, Giuliani G, Abagnale C, Altieri M, Sebastianelli G, et al. Assessment of hypothalamic macrostructure in episodic cluster headache: a volumetric segmentation MRI study. Radiol Med. 2025;130(2025):1483-8. Doi: 10.1007/s11547-025-02041-8. DOI: https://doi.org/10.1007/s11547-025-02041-8

Coppola G, Abagnale C, Sebastianelli G, Goadsby PJ. Pathophysiology of cluster headache: From the trigeminovascular system to the cerebral networks. Cephalalgia. 2024;44(2024):3331024231209317. Doi: 10.1177/03331024231209317. DOI: https://doi.org/10.1177/03331024231209317

Bai F, Huang L, Deng J, Long Z, Hao X, Chen P, et al. Prelimbic area to lateral hypothalamus circuit drives social aggression. iScience. 2023;26(2023):107718. Doi: 10.1016/j.isci.2023.107718. DOI: https://doi.org/10.1016/j.isci.2023.107718

Rizzi M, Gambini O, Marras CE. Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation. Handb Clin Neurol. 2021;182(2021):95-106. Doi: 10.1016/B978-0-12-819973-2.00007-1. DOI: https://doi.org/10.1016/B978-0-12-819973-2.00007-1

Vilela-Filho O. Commentary: Amygdala and Hypothalamus: Historical Overview With a Focus on Aggression. Neurosurgery. 2019;85(2019):E1-E3. Doi: 10.1093/neuros/nyz045. DOI: https://doi.org/10.1093/neuros/nyz045

Gouveia FV, Hamani C, Fonoff ET, Brentani H, Alho EJL, de Morais R, et al. Amygdala and Hypothalamus: Historical Overview With Focus on Aggression. Neurosurgery. 2019;85(2019):11-30. Doi: 10.1093/neuros/nyy635. DOI: https://doi.org/10.1093/neuros/nyy635

Chang CH, Gean PW. The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice. Cell Rep. 2019;28(2019):1195-205 e3. Doi: 10.1016/j.celrep.2019.07.005. DOI: https://doi.org/10.1016/j.celrep.2019.07.005

Haller J. The Role of the Lateral Hypothalamus in Violent Intraspecific Aggression-The Glucocorticoid Deficit Hypothesis. Front Syst Neurosci. 2018;12(2018):26. Doi: 10.3389/fnsys.2018.00026. DOI: https://doi.org/10.3389/fnsys.2018.00026

Hashikawa Y, Hashikawa K, Falkner AL, Lin D. Ventromedial Hypothalamus and the Generation of Aggression. Front Syst Neurosci. 2017;11(2017):94. Doi: 10.3389/fnsys.2017.00094. DOI: https://doi.org/10.3389/fnsys.2017.00094

Vaughan R. My Own Private Purgatory: How Cluster Headaches Affect My Life. Headache: The Journal of Head and Face Pain. 2008;48(2008):1541-3. Doi: 10.1111/j.1526-4610.2008.01303.x. DOI: https://doi.org/10.1111/j.1526-4610.2008.01303.x

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(2018):1-211. Doi: 10.1177/0333102417738202. DOI: https://doi.org/10.1177/0333102417738202

Downloads

Published

2025-10-16

How to Cite

1.
Valença MM, Reis RS dos, Andrade JR de. "I feel an irresistible urge to bang my head against the wall": a case series highlighting agitation and severe pain in cluster headache. Headache Med [Internet]. 2025 Oct. 16 [cited 2025 Oct. 24];16(3):180-3. Available from: https://www.headachemedicine.com.br/index.php/hm/article/view/1363

Issue

Section

Case Report